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Vitamin D plays a crucial role in cardiovascular health by regulating blood pressure, reducing inflammation and supporting endothelial function, in addition to its classical application. Vitamin D deficiency is associated with multiple cardiovascular risk factors, a heightened risk of heart disease and disruptions in several systems that regulate heart health. Fermenta, a leading manufacturer of Vitamin D, presents this D-Essence Newsletter to highlight the latest research on the Role of Vitamin D in Cardiovascular Health.
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Vitamin D supplementation might suppress renin in chronic heart failure
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A randomized double-blind trial evaluated the impact of Vitamin D supplementation (Vs. placebo) on the renin-angiotensin-aldosterone system in chronic heart failure patients with reduced ejection fraction. Overall, comparable patients had hypovitaminosis D (<30 ng/mL: 90% and 85%) and hyper-reninemia (80% and 75%) at baseline in the Vitamin D (n=40) and placebo group (n=40), respectively. After 1 month of Vitamin D supplementation, there was a 26.9 ng/ml greater increase in Vitamin D levels from baseline compared to placebo. Additionally, Vitamin D supplementation lowered the renin concentration by -40.5 pg/ml from baseline Vs. +5.7 pg/ml increase in the placebo group.
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| Mghaieth F et al. Glob Cardiol Sci Pract. 2025 Feb 28;2025(1):e202507 |
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Vitamin D may alleviate hypertriglyceridemia in overweight/obese women
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A meta-analysis and systematic review of 13 eligible publications examined the impact of Vitamin D supplementation on lipid profile in women who are overweight/obese. Vitamin D supplementation was associated with a reduction of 6.13 mg/dL and 4.45 mg/dL in triglyceride (TG) and total cholesterol level, respectively, as calculated by weighted mean difference. Additionally, Vitamin D supplementation also significantly increased the HDL-C levels by 1.54 mg/dL. The greater reduction in TG levels was observed in studies that had a mean baseline TG concentration of ≥150 mg/dL (-23.58 mg/dL) and when Vitamin D was administered for ≤26 weeks (-11.44 mg/dL).
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| Hu L et al. Nutr Rev. 2025 Sep 1;83(9):1657-1668 |
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Higher serum Vitamin D levels potentially mitigate CV outcomes
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The association between serum Vitamin D levels and its CV outcomes was analyzed in a systematic review and meta-analysis study. Among 22 included articles, low serum Vitamin D level (<75 nmol/L) was associated with a 38% and 64% increased risk of CV events and all-cause mortality, respectively. The dose-response analysis revealed that each 10-unit increase in Vitamin D concentration was associated with an 8.2% risk reduction of CVD. Additionally, there was also a significant inverse correlation between Vitamin D levels and mortality risk (p < 0.001 for non-linearity). |
| Madadi R et al. J Saudi Heart Assoc. 2025 Jun 1;37(2):14 |
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Disclaimer: The contents of this issue of ‘D-essence’ have been developed by FourC Healthvistas Pvt. Ltd. for Fermenta Biotech Ltd. (and its group companies) from information published in literature or sources as cited. The information presented in this publication is for general information and educational purpose only, and it shall neither be considered as any claim, nor as a substitute for professional medical advice, nor is intended to diagnose, treat, cure or prevent any disease. Although a great care has been taken in compiling and checking the information, it has not been evaluated by United States Food and Drug Administration or any authority. The authors, FourC Healthvistas Pvt. Ltd., Fermenta Biotech Ltd., and their respective employees, directors, managers, agents & sponsors shall not be responsible and in any way liable for any errors, omissions or inaccuracies in this publication, whether arising out of negligence, mistake or otherwise, and for any consequences arising therefrom.
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