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Vitamin D plays a crucial role beyond bone health, with growing evidence linking it to mental well-being. Vitamin D is a neuroprotective hormone that is known to regulate many essential genes involved in brain function. Several studies indicate that Vitamin D deficiency may be associated with an increased risk of developing depression. Fermenta, a leading manufacturer of Vitamin D, presents this D-Essence Newsletter to highlight the latest research on the Role of Vitamin D in Mental Health.
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Vitamin D supplementation might serve as an adjunctive therapy for depression
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A meta-analysis of 20 randomized controlled trials examined the impact of Vitamin D supplementation on depressive symptoms (estimated using different score scales). Among individuals with depression, Vitamin D supplementation resulted in a significant reduction in the total score of depressive symptoms with a standardized mean difference of -0.36. Subgroup analysis revealed a marked reduction of depression score with Vitamin D in long-term interventions of >1 year as well as in ulcerative colitis patients and dialysis-dependent individuals, highlighting its therapeutic potential in inflammatory/metabolic disorders.
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| Wang L et al. Front Psychiatry. 2025 Jul 31;16:1622796 |
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Vitamin D sufficiency potentially mitigates depression risk in diabetes
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The correlation between serum Vitamin D levels and depression risk among pre-diabetes and diabetes patients was analyzed in a prospective cohort study. At baseline, only 9.5% and 6.7% patients with pre-diabetes and diabetes, respectively, had sufficient Vitamin D levels (≥75 nmol/L). After multivariable adjustment, there was an inverse and dose-dependent association between serum Vitamin D levels and risk of depression in pre-diabetes and diabetes populations. Compared to participants with severe Vitamin D deficiency (<25 nmol/L), there was a 17% and 25% lower risk of depression in those with Vitamin D sufficiency among pre-diabetes and diabetes patients, respectively.
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| Li H et al. J Nutr Health Aging. 2025 Jun;29(6):100556 |
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Vitamin D supplementation may effectively reduce depressive symptoms
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The dose-dependent impact of Vitamin D supplementation on depression symptoms was evaluated in a systematic review and dose-response meta-analysis of 31 randomized controlled trials. Every 1000 IU/day Vitamin D supplementation slightly reduced depressive symptoms with a standardized mean difference (SMD) of -0.32, with a more pronounced improvement observed among those with a history of depression (SMD: -0.57). The depression symptoms decreased with a proportionate increase in Vitamin D dosage for up to 8000 IU/day. Additionally, trials with a follow-up of ≤8 weeks and 8 to ≤24 weeks showed superior efficacy compared to those lasting 24 to ≤52 weeks or >52 weeks. |
| Ghaemi S et al. Psychol Med. 2024 Nov 18;54(15):1-10 |
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Disclaimer: The contents of this issue of ‘D-essence’ have been developed by FourC Healthvistas Pvt. Ltd. for Fermenta Biotech Ltd. (and its group companies) from information published in literature or sources as cited. The information presented in this publication is for general information and educational purpose only, and it shall neither be considered as any claim, nor as a substitute for professional medical advice, nor is intended to diagnose, treat, cure or prevent any disease. Although a great care has been taken in compiling and checking the information, it has not been evaluated by United States Food and Drug Administration or any authority. The authors, FourC Healthvistas Pvt. Ltd., Fermenta Biotech Ltd., and their respective employees, directors, managers, agents & sponsors shall not be responsible and in any way liable for any errors, omissions or inaccuracies in this publication, whether arising out of negligence, mistake or otherwise, and for any consequences arising therefrom.
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