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Vitamin D has a potential impact on the optimization of diabetes control and prevention of various diabetes complications, besides its role in calcium and bone homeostasis. Vitamin D supplementation is known to effectively lower blood glucose, improve insulin sensitivity and promote anti-inflammatory response. Fermenta, a leading manufacturer of Vitamin D, presents this D-Essence Newsletter to highlight the latest research on the Role of Vitamin D in Blood Sugar Regulation.
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Vitamin D supplementation may offer glycemic and lipid control in diabetes
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The impact of Vitamin D supplementation on glycemic control and lipid profile among 254 individuals with diabetes and Vitamin D deficiency (< 50 nmol/L) was investigated in a retrospective hospital-based study. After receiving Vitamin D supplements for ≥3 months, the mean Vitamin D level increased by 20.1 nmol/L compared to baseline, with 97.2% patients achieving sufficiency (> 50 nmol/L). Additionally, Vitamin D supplementation significantly lowered HbA1c, FBG and LDL levels by 1.1%, 1.2 mmol/L and 0.5 mmol/L, respectively, Vs. baseline. Vitamin D supplementation resulted in the control of HDL and TC levels in 55.6% and 34.7% of patients who presented with their respective uncontrolled levels at baseline.
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| Alqadi A et al. Eur Rev Med Pharmacol Sci. 2025 May;29(5):248-257
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Vitamin D deficiency possibly elevates diabetic complications in T2DM
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The association between Vitamin D status and diabetic complications among T2DM patients was assessed in a case-control study (case: n = 873 and control: n = 566). After adjusting for appropriate variables, Vitamin D deficiency (<20 ng/mL) was found to be a significant predictor for the development of diabetic complications: with a greater odds of experiencing neuropathy (4-fold), nephropathy (5-fold), retinopathy (2.5-fold), ischemic heart disease (2-fold) and diabetic foot disease (2.7-fold). Vitamin D levels were significantly correlated with factors affecting sun exposure like gender, place of residence and type of occupation.
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| Chackochan A et al. Nutr Health. 2025 Jul 24:2601060251359708 |
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Vitamin D supplementation might promote diabetic foot ulcer healing
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A meta-analysis of 7 studies evaluated the impact of Vitamin D supplementation on diabetic foot ulcer healing. Among 580 patients, Vitamin D supplementation was associated with a 42% greater rate of wound healing efficiency compared to the control group. Additionally, Vitamin D supplementation improved glucose metabolism and insulin indexes estimated by HbA1c, fasting insulin and HOMA-β with a mean difference of -0.44, -3.75 and -5.14, respectively, Vs. control (P < 0.01 for each). Furthermore, Vitamin D supplementation also reduced inflammation and oxidative stress. |
| Wu X et al. Postgrad Med J. 2025 Jan 23;101(1192):100-107 |
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Disclaimer: The contents of this issue of ‘D-essence’ have been developed by FourC Healthvistas Pvt. Ltd. for Fermenta Biotech Ltd. (and its group companies) from information published in literature or sources as cited. The information presented in this publication is for general information and educational purpose only, and it shall neither be considered as any claim, nor as a substitute for professional medical advice, nor is intended to diagnose, treat, cure or prevent any disease. Although a great care has been taken in compiling and checking the information, it has not been evaluated by United States Food and Drug Administration or any authority. The authors, FourC Healthvistas Pvt. Ltd., Fermenta Biotech Ltd., and their respective employees, directors, managers, agents & sponsors shall not be responsible and in any way liable for any errors, omissions or inaccuracies in this publication, whether arising out of negligence, mistake or otherwise, and for any consequences arising therefrom.
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