Vitamin D is well known for its central role in calcium and phosphorus homeostasis and bone metabolism. Many observational studies suggest various extra-skeletal effects of Vitamin D, particularly linking its deficiency to cardiovascular and cardiometabolic disease risk factors, inflammatory pathways, as well as impaired muscle action and strength. Fermenta, a leading manufacturer of Vitamin D, presents this D-Essence Newsletter to highlight the latest research on the Role of Vitamin D in general health and wellness. Vitamin D supplementation might improve deficiency-related symptoms The influence of Vitamin D supplementation (50,000 IU/week) on symptoms and clinical outcomes (fatigue, muscle pain and discomfort) in adults with insufficient (30–50 nmol/L) or deficient (<30 nmol/L) baseline Vitamin D levels was investigated in an interventional study. Among 204 participants, 65.1% had Vitamin D deficiency at baseline. After 2 months of Vitamin D supplementation, the symptoms were significantly improved in patients who achieved Vitamin D sufficiency (>50 nmol/L). After adjusting for confounders, baseline Vitamin D deficiency was one of the significant predictors of symptom improvement post-supplementation. Albasheer O et al. J Health Popul Nutr. 2025 May 29;44(1):176 Vitamin D supplementation probably optimizes muscle function in athletes The impact of Vitamin D supplementation on muscle function and exercise performance of high school athletes was assessed in a study. Among 21 athletes, only 28.6% had Vitamin D sufficiency (>30 ng/mL) with a mean level of 35.8 ng/mL. After daily 1,000 IU Vitamin D supplementation for 6 months, serum Vitamin D level increased significantly by 40%, 30% and 45% in total, male and female athletes, respectively. Furthermore, Vitamin D supplementation significantly improved anaerobic capacity (estimated by Wingate Anaerobic Power Test), peak power and maximal cycling in all athletes. Nakajima H et al. J Med Invest. 2025;72(1.2):167-171 Vitamin D level may correlate with cardiometabolic parameters in obese adults A cross-sectional study explored the interrelation between Vitamin D status and cardiometabolic markers in extremely obese (BMI >35 kg/m²) individuals. Among 293 subjects included, 81% had Vitamin D deficiency (< 20 ng/mL) with a mean BMI of 42 kg/m². The Spearman correlation analysis revealed that total serum Vitamin D level was negatively associated with BMI (P < 0.0001) and parathyroid hormone (P < 0.0001). Additionally, on regression analysis, higher Vitamin D level was associated with higher HDL-C and apolipoprotein A-1 levels, which remained significant after adjusting for confounding variables. Zhou Y et al. Int J Endocrinol. 2025 Jun 26;2025:7945302 Disclaimer: The contents of this issue of ‘D-essence’ have been developed by FourC Healthvistas Pvt. Ltd. for Fermenta Biotech Ltd. (and its group companies) from information published in literature or sources as cited. The information presented in this publication is for general information and educational purpose only, and it shall neither be considered as any claim, nor as a substitute for professional medical advice, nor is intended to diagnose, treat, cure or prevent any disease. Although a great care has been taken in compiling and checking the information, it has not been evaluated by United States Food and Drug Administration or any authority. The authors, FourC Healthvistas Pvt. Ltd., Fermenta Biotech Ltd., and their respective employees, directors, managers, agents & sponsors shall not be responsible and in any way liable for any errors, omissions or inaccuracies in this publication, whether arising out of negligence, mistake or otherwise, and for any consequences arising therefrom. For more information, please visit our public awareness initiative All Rights Reserved Fermenta Biotech Ltd.