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Vitamin D is well-known for its crucial role in calcium metabolism, bone health and immune function. Additional functional roles of Vitamin D have been documented wherein its deficiency is often associated with various metabolic factors, diseases and their outcomes. Fermenta, a leading manufacturer of Vitamin D, presents this D-Essence Newsletter to highlight the latest research on Vitamin D and its role in maintaining overall health and wellness.
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Vitamin D supplementation might improve hemodynamic parameters and autonomic balance in obese/overweight individuals
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A prospective, randomized clinical trial assessed the impact of Vitamin D supplementation on central hemodynamic parameters and autonomic activity in 53 obese/overweight individuals with low Vitamin D levels. At week 8, Vitamin D supplementation increased serum Vitamin D levels (+13 ng/mL) and decreased alkaline phosphatase (-11 mg/dl). The SBP and arterial pressure reduced significantly by 4 mmHg with Vitamin D supplementation. Vitamin D substantially improved autonomic activity parameters like parasympathetic nervous system index, beat-to-beat RR interval, heart rate, sympathetic nervous system index and stress index.
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| Faria ACC et al. Arq Bras Cardiol. 2024 Apr;121(5):e20230678
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Vitamin D supplementation potentially lowers mortality risk among COPD patients in ICU
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The correlation between Vitamin D supplementation and the prognoses of COPD patients in ICU was evaluated in a retrospective study. Compared to patients who received Vitamin D supplementation (n = 587), there was a 70% and 80% higher risk of in-hospital and ICU mortality, respectively, among those who did not receive (n = 2,616). On subgroup analysis, a significant interaction between gender and in-hospital mortality was observed with female patients showing better survival. The survival probability was significantly increased in patients using Vitamin D >7 days Vs. those using Vitamin D ≤7 days.
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| He Q et al. Front Med (Lausanne). 2024 Mar 22;11:1334524
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Vitamin D supplementation may have beneficial effect on lipid profiles
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A longitudinal study, including 345 women with different status of Vitamin D levels, attempted to determine the Vitamin D supplementation duration to reach an optimal status and its effect on lipid profiles. After 1 year of supplementation, the change in serum Vitamin D level was +10 ng/mL, +7.3 ng/mL and +6.4 ng/mL in deficiency (< 20 ng/mL), inadequate (20-30 ng/mL) and adequate group (> 30 ng/mL), respectively, vs. 3rd month. Vitamin D supplementation reduced LDL-C & total cholesterol in deficiency (-5.9 & -12.2 mg/dl), inadequate (-7.2 & -13.6 mg/dl) and adequate (-6.2 & -17.8 mg/dl) group, respectively, from baseline. The triglyceride levels decreased by -13.2 and -15.8 mg/dl in deficiency and adequate group, respectively.
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| Saeidlou SN et al. J Health Popul Nutr. 2024 Jun 12;43(1):81
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Disclaimer: The contents of this scientific issue have been developed by FourC Healthvistas Pvt. Ltd. for Fermenta Biotech Ltd., from reasonable and reliable information published in literature as cited. This is for information purpose only and not a substitute to medical advice. Although great care has been taken in compiling and checking the information, the authors, FourC Healthvistas Pvt. Ltd., Fermenta Biotech Ltd., its employees and/or its agents & sponsors shall not be responsible, or in anyway liable for any errors, omissions or inaccuracies in this publication, whether arising from negligence or otherwise, or for any consequences arising therefrom.
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All Rights Reserved Fermenta Biotech Ltd.
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