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A strong correlation is found between Vitamin D and respiratory health as its deficiency is associated with higher prevalence of respiratory diseases, impaired pulmonary function, airway inflammation and infections. The intake of Vitamin D can most likely regulate these critical factors and improve lung functionality. Fermenta, one of the largest manufacturers of Vitamin D, brings to you this Newsletter on the latest research of Vitamin D in Respiratory Diseases.
Vitamin D supplementation might enhance lung function in COPD patients
A systematic review and meta-analysis of 19 articles evaluated the impact of Vitamin D on the lung function of COPD patients. As compared to patients not receiving Vitamin D supplementation, those treated with Vitamin D supplementation showed a greater improvement in lung function, calculated by FEV1 and FEV1/FVC% levels, of 6.39 and 6.88, respectively, from baseline. Vitamin D supplementation was associated with 64% lesser odds of acute exacerbations Vs. control. Vitamin D supplementation significantly improved T cell subset levels (CD3+, CD4+ and CD4+/CD8+) and lowered the impact of COPD on patients’ life.
Li M et al. Nutrients. 2024 Apr 1;16(7):1028
Vitamin D supplementation may reduce asthma incidence in overweight and obese individuals
A cross-sectional study assessed the association between Vitamin D levels and asthma in overweight and obese population. Among 3,889 individuals, the asthma prevalence decreased with increasing dietary Vitamin D supplementation up to 24.8 mcg dosage. After adjusting for confounding variables, those with insufficient and sufficient Vitamin D levels (46.7 to ≥78.3 nmol/L) had about 17-35% lesser odds of asthma Vs. those with moderate to severe deficiency (10.2-46.6 nmol/L). There was a 9.5% decrease in asthma risk with every 10 nmol/L increase in Vitamin D levels and this correlation remained significant till 84.95 nmol/L.
Shi X et al. J Asthma. 2024 Jul;61(7):685-697
Vitamin D supplementation potentially mitigates respiratory infection in pre-school children
The influence of Vitamin D supplementation on the respiratory infection incidences among pre-school children was investigated in a cross-sectional study. The sample consisting of 215 children was distributed into two groups: those with recurrent respiratory infections group (n=141) and those without (n=74). As compared to the non-recurrent group, 2-fold more children with Vitamin D deficiency (20-16 ng/mL) had recurrent infection. The number of respiratory infections increased with decreasing Vitamin D level. Children receiving >600 IU/week of Vitamin D supplementation were about 50% less likely to experience respiratory infection Vs. those who did not receive.
Sarau OS et al. Nutrients. 2024 May 23;16(11):1595
Disclaimer: The contents of this scientific issue have been developed by FourC Healthvistas Pvt. Ltd. for Fermenta Biotech Ltd., from reasonable and reliable information published in literature as cited. This is for information purpose only and not a substitute to medical advice. Although great care has been taken in compiling and checking the information, the authors, FourC Healthvistas Pvt. Ltd., Fermenta Biotech Ltd., its employees and/or its agents & sponsors shall not be responsible, or in anyway liable for any errors, omissions or inaccuracies in this publication, whether arising from negligence or otherwise, or for any consequences arising therefrom.
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