Vitamin D has an established role in calcium homeostasis but its deficiency is emerging as a new risk factor for various chronic diseases affecting metabolic, auto-immune, cardiovascular and neurological pathways. Vitamin D supplementation might provide marked protection against these chronic diseases and their risk factors. Fermenta, one of the largest manufacturers of Vitamin D, brings to you this Newsletter on the latest research of Vitamin D in Chronic Illness. Vitamin D supplement may reduce disease activity & fatigue in rheumatoid arthritis patients A prospective randomized clinical trial evaluated the effect of Vitamin D supplementation on disease activity and fatigue in 68 rheumatoid arthritis (RA) patients. After 12 weeks, Vitamin D supplementation showed an 18 nmol/l greater improvement in mean Vitamin D level Vs. without supplementation. Vitamin D maintained the fatigue level at normal range with a mean score of 36 (measured by Functional Assessment of Chronic Illness Therapy-Fatigue) whereas without supplementation, the fatigue level stayed at an abnormal range (<27.75). Additionally, there was an inverse correlation between Vitamin D levels and RA disease activity. Elfituri S. Reumatologia. 2024;62(2):109-114 Vitamin D supplementation possibly mitigates dementia outcomes A prospective cohort study analyzed the association of Vitamin D status and supplementation, with dementia outcomes. Among 2,69,229 participants, 18% and 34% of patients had Vitamin D deficiency (<30 nmol/L) and insufficiency (<50 nmol/L), respectively, with only 5% consuming Vitamin D regularly. As compared to Vitamin D sufficiency (≥50 nmol/L), there was a 25% and 11% greater risk of all-cause dementia with deficiency and insufficiency, respectively. Furthermore, Vitamin D supplementation reduced the risk of Alzheimer’s disease, all-cause dementia and vascular dementia incidence by 17%, 10% and 10%, respectively. Chen LJ et al. Am J Clin Nutr. 2024 Apr;119(4):1052-1064 Vitamin D supplementation is likely associated with cardiovascular risk factors in T2DM A cross-sectional study examined the association between Vitamin D status and cardiovascular (CV) risk factors among 318 T2DM patients. While analyzing the Vitamin D status, 66% of patients had hypovitaminosis D; wherein 45% had insufficiency (20-29 ng/mL) and 21% had deficiency (≤19 ng/mL). The risk factors for hypovitaminosis D were found to be age ≥70 yrs, HbA1c ≥7% and retinopathy. After adjusting for these risk factors, hypovitaminosis D demonstrated 9-, 8-, 6-, 3- and 3-fold greater odds of the CV risk factors of hypertension, dyslipidemia, ex-smoking, microalbuminuria and carotid atherosclerosis, respectively, in T2DM patients. Raharinavalona SA et al. Diabetes Metab Syndr Obes. 2024 May 31;17:2191-2198 Disclaimer: The contents of this scientific issue have been developed by FourC Healthvistas Pvt. Ltd. for Fermenta Biotech Ltd., from reasonable and reliable information published in literature as cited. This is for information purpose only and not a substitute to medical advice. Although great care has been taken in compiling and checking the information, the authors, FourC Healthvistas Pvt. Ltd., Fermenta Biotech Ltd., its employees and/or its agents & sponsors shall not be responsible, or in anyway liable for any errors, omissions or inaccuracies in this publication, whether arising from negligence or otherwise, or for any consequences arising therefrom. For more information, please visit our public awareness initiative All Rights Reserved Fermenta Biotech Ltd.