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Vitamin D is a pivotal regulator of immune function and inflammation apart from its conventional role in calcium and bone homeostasis. Maintaining an optimal level of Vitamin D regulates inflammatory markers and protects against certain inflammatory-related conditions. Fermenta, a leading manufacturer of Vitamin D, presents this D-Essence Newsletter to highlight the latest research on Vitamin D and its impact on inflammation. |
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Vitamin D might influence inflammatory cytokines among adults
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The interplay between Vitamin D status and inflammatory cytokines was evaluated in a cross-sectional study which enrolled 500 healthy adults. Overall, there was a statistically significant negative correlation between Vitamin D and the pro-inflammatory cytokines, TNF-α and INF-γ. Meanwhile, a positive association was found between Vitamin D and the anti-inflammatory cytokine IL-10 (p <0.0001). The most accurate biochemical marker for predicting Vitamin D deficiency was INF-γ, followed by TNF-α and IL-10 (p <0.0001 for each biomarker). The odds of developing Vitamin D deficiency increased with decreasing IL-10 levels and increasing TNF-α and INF-γ levels. |
| Antwi MH et al. BMC Res Notes. 2024 Mar 4;17(1):64
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Vitamin D deficiency potentially increase inflammation & CV death in CHD
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The impact of Vitamin D deficiency (VDD) on inflammation and adverse outcomes among coronary heart disease (CHD) was analyzed in a study. Of 5,452 participants, 44% had VDD (<20 ng/mL) and these patients had a 57% higher risk of CV death compared to those without deficiency, after adjusting for multiple covariates. In patients with VDD, there was a 33% and 45% higher level of hsCRP (inflammatory marker) Vs. those with insufficiency (20-30 ng/mL) and normal level (>30 ng/mL), respectively. Individuals with both VDD and elevated hsCRP (>3 mg/L) had a 2.8-fold greater risk of CV mortality Vs. those without deficiency and lower level of hsCRP (<3 mg/L).
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| Desai SR et al. JACC Adv. 2024 Jan 4;3(2):100804 |
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Vitamin D may have an inverse correlation with inflammatory markers in T2D
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A study investigated the prevalence of Vitamin D deficiency and its association with inflammatory markers in type 2 diabetes (T2D) patients. Among 2,806 individuals, >80% patients had Vitamin D levels <30 ng/mL with the prevalence of Vitamin D deficiency (<20 ng/mL) exceeding 60% in female. Overall, as Vitamin D levels increased, there was a significant decrease in various inflammatory markers like hsCRP, erythrocyte sedimentation rate (ESR), white blood cell (WBC) count, neutrophil count and monocyte count. After adjusting for age and gender, a negative correlation was noted between ESR, hsCRP, WBC and Vitamin D levels in multiple regression analysis.
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| Shan R et al. Open Life Sci. 2024 May 28;19(1):20220787
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Disclaimer: The contents of this issue of ‘D-essence’ have been developed by FourC Healthvistas Pvt. Ltd. for Fermenta Biotech Ltd. (and its group companies) from information published in literature or sources as cited. The information presented in this publication is for general information and educational purpose only, and it shall neither be considered as any claim, nor as a substitute for professional medical advice, nor is intended to diagnose, treat, cure or prevent any disease. Although a great care has been taken in compiling and checking the information, it has not been evaluated by United States Food and Drug Administration or any authority. The authors, FourC Healthvistas Pvt. Ltd., Fermenta Biotech Ltd., and their respective employees, directors, managers, agents & sponsors shall not be responsible and in any way liable for any errors, omissions or inaccuracies in this publication, whether arising out of negligence, mistake or otherwise, and for any consequences arising therefrom.
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