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Vitamin D is closely linked to endocrine system and hormonal balance in addition to its prominent role in skeletal health. Inadequate level of Vitamin D serves as a risk factor for various endocrine disorders, impaired tissue regeneration, developing infections, PCOS, thyroid and parathyroid dysfunction, etc. Fermenta, a leading manufacturer of Vitamin D, presents this D-Essence Newsletter to highlight the latest research on Vitamin D and its effect on different glands present in human body. |
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Vitamin D sufficiency may positively influence thymosin β4 level
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A study explored the influence of Vitamin D on the thymic hormone thymosin β4 and CD4 cells. Of 35 subjects screened for Vitamin D level, 10 participants had sufficient level: > 20 ng/ml and 25 suffered from severe Vitamin D deficiency: < 12 ng/ml. Patients with Vitamin D sufficiency had a 29.6 µg/L and 7.6E2 ng/ml higher level of Vitamin D (P = 0.001) and thymosin β4 (P = 0.005), respectively, compared to those with Vitamin D deficiency. Furthermore, a significant positive association was noted between Vitamin D, thymosin β4 and CD4.
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| Sibaii H et al. Open Access Maced J Med Sci. 2016 Dec 15;4(4):591-595
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Vitamin D supplementation might positively influence the hormonal profile in PCOS
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The effect of Vitamin D on the hormonal profile of women with PCOS was estimated in this systematic review and meta-analysis which included 19 articles. After intervention, Vitamin D significantly reduced dehydroepiandrosterone sulfate (typically high in PCOS), testosterone, luteinizing hormone and free androgen index levels with a standardized mean difference (SMD) of 0.24, 0.71, 0.22 and 0.37, respectively, compared to before intervention. Additionally, Vitamin D intervention elevated the sex hormone-binding globulin (low level correlated with PCOS) level by an SMD of 0.33 Vs. before intervention.
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| Kazeminia M et al. Middle East Fertility Society Journal. 2024;29:45 |
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Maintaining adequate Vitamin D level probably lowers the odds of thyroid disorders
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A mendelian randomization of two-sample investigated the causal effect of Vitamin D on the thyroid function. A suggestive causal effect of Vitamin D on high thyroid-stimulating hormone (TSH) and autoimmune hypothyroidism was observed irrespective of different analysis methods used. With each 1 SD increase in Vitamin D, there was a 12% and 16.34% lower risk of high TSH and autoimmune hypothyroidism, respectively (P = 0.02 for both). This indicates that maintaining adequate level of Vitamin D may improve thyroid function by lowering the risk of the emergence of thyroid disorders.
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| Pleić N et al. PLoS One. 2024 Jun 20;19(6):e0304253
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Disclaimer: The contents of this issue of ‘D-essence’ have been developed by FourC Healthvistas Pvt. Ltd. for Fermenta Biotech Ltd. (and its group companies) from information published in literature or sources as cited. The information presented in this publication is for general information and educational purpose only, and it shall neither be considered as any claim, nor as a substitute for professional medical advice, nor is intended to diagnose, treat, cure or prevent any disease. Although a great care has been taken in compiling and checking the information, it has not been evaluated by United States Food and Drug Administration or any authority. The authors, FourC Healthvistas Pvt. Ltd., Fermenta Biotech Ltd., and their respective employees, directors, managers, agents & sponsors shall not be responsible and in any way liable for any errors, omissions or inaccuracies in this publication, whether arising out of negligence, mistake or otherwise, and for any consequences arising therefrom.
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