|
|
|
|
Vitamin D has been implicated in many physiological processes including insulin synthesis, secretion and action. Majority of diabetes patients suffer from Vitamin D deficiency which has been linked to insulin resistance. In recent years, Vitamin D supplementation has gained increasing attention for promoting blood glucose control and enhancing insulin secretion in diabetes patients. Fermenta, one of the largest manufacturers of Vitamin D, brings to you this Newsletter on the latest research of Vitamin D in Diabetes.
|
|
|
Vitamin D supplementation supports improved glucose & lipid metabolism in T2DM patients
|
|
In a retrospective study of 162 diabetes (T2DM) patients divided into an insulin resistance (IR) and a non-resistance group, the resistance group had significantly lower levels of Vitamin D (35.9 Vs. 44.8 nmol/L). Vitamin D was found to be an independent risk factor for IR associated with 26-fold increased odds (OR: 26.1). IR patients were further subdivided into 1) Conventional T2DM treatment group, 2) Vitamin D supplementation + conventional treatment group. The Vitamin D group exhibited significantly greater reductions in fasting and post-prandial glucose, HbA1c, cholesterol, triglyceride levels and better improvement in high-density lipoprotein cholesterol levels Vs. the conventional group.
|
| Sun LJ et al. World J Diabetes. 2023 Oct 15;14(10):1514-1523 |
|
|
|  |
|
|
|
Vitamin D deficiency might increase the risk of diabetic neuropathy
|
|
|
A cross-sectional study examined the link between Vitamin D deficiency and diabetic peripheral neuropathy (DPN) in 257 elderly type 2 diabetes patients. Vitamin D deficient patients had a significantly higher prevalence of neuropathy (80.4% Vs. 64%). Vitamin D was identified as an independent risk factor for DPN with 2.5-fold increased odds (OR: 2.48). Vitamin D was negatively correlated with nerve motor & sensory latency and positively correlated with nerve velocities & amplitude which indicated that Vitamin D deficiency might increase the risk of DPN and promote its development by affecting large nerve fibers. |
| Fei S et al. Diabetes Res Clin Pract. 2024 Feb 15;209:111585
|
|
|
|
|
|
Low Vitamin D might elevate the risk of kidney disease in diabetes patients
|
|
|
The relationship of Vitamin D with kidney disease was investigated among 328 diabetes patients. More than 1 in 2 patients had insufficient or deficient levels of Vitamin D (<30 ng/mL). A significant negative correlation was observed between Vitamin D levels and the kidney function parameters of blood urea nitrogen and serum creatinine. Additionally, patients with an HbA1c of >7% were more likely to be Vitamin D deficient indicating an inverse relationship. Diabetes patients with Vitamin D deficiency are associated with a greater probability of poor glycemic control and the development of diabetic nephropathy.
|
| Obaid AA et al. Diabetes Metab Syndr Obes. 2024 Jan 3;17:11-17
|
|
|
|
|
|
|
|
Disclaimer: The contents of this scientific issue have been developed by FourC Healthvistas Pvt. Ltd. for Fermenta Biotech Ltd., from reasonable and reliable information published in literature as cited. This is for information purpose only and not a substitute to medical advice. Although great care has been taken in compiling and checking the information, the authors, FourC Healthvistas Pvt. Ltd., Fermenta Biotech Ltd., its employees and/or its agents & sponsors shall not be responsible, or in anyway liable for any errors, omissions or inaccuracies in this publication, whether arising from negligence or otherwise, or for any consequences arising therefrom.
|
|
|
|
For more information, please visit our public awareness initiative
|
|
|
|
|
|
All Rights Reserved Fermenta Biotech Ltd.
|
|
