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Vitamin D has been consistently recognized to regulate immune response by modulating multiple inflammatory pathways and maintaining homeostasis. According to prior research, Vitamin D is affiliated with the respiratory system and its deficiency may impair lung function and increase the risk of respiratory tract infections. Fermenta, one of the largest manufacturers of Vitamin D, brings to you this Newsletter on the latest research of Vitamin D in Respiratory Illness.
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Vitamin D supplementation might mitigate the severity of chronic obstructive pulmonary disease (COPD)
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A study examined the correlations between Vitamin D and disease severity in 65 patients with acute exacerbation of COPD. Compared to healthy individuals, COPD patients showed a 2-fold lower level of Vitamin D (P <0.05) along with notably greater level of IL-1β (a pro-inflammatory cytokine). Additionally, Vitamin D was negatively associated with the severity of COPD (measured by mMRC and CAT scores). On analyzing the clinical diagnostic value, it was implied that Vitamin D can be adopted as one of the reference indexes for the diagnosis of COPD and Vitamin D supplementation might be considered during COPD treatment.
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| Wang L et al. Cell Mol Biol (Noisy-le-grand). 2023 Dec 31;69(15):21-25 |
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Vitamin D level might be inversely associated with respiratory infection
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A cross-sectional study analyzed the association between Vitamin D levels and respiratory infection in adults. Among 31,466 participants, average level of Vitamin D was insufficient (66.19 nmol/L). On comparing with the sufficient group (≥75 nmol/L), Vitamin D insufficiency (50-74.9 nmol/L) and severe deficiency (<30 nmol/L) was associated with 21% and 84% greater odds of respiratory infection (including influenza, pneumonia or ear infection) and 12% and 17% greater odds of head or chest colds, respectively. This indicates that lower level of Vitamin D increases the risk of respiratory infections. |
| Li B et al. J Nutr. 2023 Jan;153(1):260-267
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Optimal Vitamin D level might lower the risk of adult-onset asthma
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A prospective, cohort study investigated the association between Vitamin D concentration and the incidence of adult-onset asthma. Among 307,872 participants, optimal Vitamin D level (>50 nmol/L) was inversely associated with incident asthma indicated by 11% greater reduction in the risk of asthma as compared to the deficient level (<25 nmol/L). The positive impact of Vitamin D was significant among men, individuals <60 years of age, overweight, current and previous smokers with 23%, 14%, 14%, 24% and 15% greater risk reduction of incident asthma, respectively, as compared to deficient level.
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| Chang Q et al. Front Nutr. 2023 Jun 30;10:1222499
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Disclaimer: The contents of this scientific issue have been developed by FourC Healthvistas Pvt. Ltd. for Fermenta Biotech Ltd., from reasonable and reliable information published in literature as cited. This is for information purpose only and not a substitute to medical advice. Although great care has been taken in compiling and checking the information, the authors, FourC Healthvistas Pvt. Ltd., Fermenta Biotech Ltd., its employees and/or its agents & sponsors shall not be responsible, or in anyway liable for any errors, omissions or inaccuracies in this publication, whether arising from negligence or otherwise, or for any consequences arising therefrom.
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