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Vitamin D3 and Penicillin G Acylase

BUSINESS DIVISION - Vitamin D3 in Crystalline & OIL, Vitamin D3 Resin, Vitamin D3 Feed and Food Grade

 

Vitamin D3 : (Cholecalciferol)

 

     Molecular Formula
     C27H44O
 

     Chemical Name
     (5Z,7E)-9,10-secocholesta-5,7,10 (19)-trien-3ß-ol


     Molecular Weight
     384.64

          Structural Formula     

Vitamin D3 Cholecalciferol

 

Vitamin D is a steroid Vitamin, a group of fat-soluble prohormones that help maintain the balance of calcium in the body, important for normal growth and mineralization of bones and teeth. Extensive and ongoing research on Vitamin D has also brought to light new roles of this Vitamin in modulation of cell growth, neuromuscular and immune functions.

Vitamin D - Background

In the 1920's Edward Mellanby and Elmer McCollum discovered an anti-rachtic factor in cod liver oil while researching a cure for the disease rickets. McCollum identified the factor to be distinct

from Vitamin A in 1922 and called it Vitamin D as it was the fourth Vitamin to be named.

In 1927 Dr. E. H. Reerink and Dr. A. van Wijk, two young scientists in the Phillips’ Physics Laboratory in Eindhoven, the Netherlands, used the newly developed high pressure ultraviolet lamp to obtain reaction products from ergosterol by careful wavelength monitoring. They achieved the first industrial scale photochemical transformation of ergosterol into an anti-rachtic substance which was a synthetic method of producing pure Vitamin D. The road to important pharmaceutical activities was opened, for the health of man and animals. Vitamin D3 synthesis

Vitamin D3 – Synthesis & metabolism in the body

 

The epidermis and dermis layers of the skin contain 7-dehydrocholesterol also known as provitamin D3 which on exposure to Ultra Violet radiation between 290 – 315 nm (UVB range) is synthesized to Vitamin D3.

Vitamin D3 synthesized on the skin and consumed in food is converted into the metabolite 25(OH)D3 i.e. 25-hydroxyvitamin D3 or calcidiol in the liver in the presence of the enzyme 25-hydroxylase.

The metabolite 25(OH)D3 is the major circulating form of Vitamin D3 in the blood.

In the kidney 25(OH)D3 is converted into 1,25(OH)2D3 i.e. 1,25 dihydroxyvitamin D3 or calcitriol which is the active form of Vitamin D3 required by the body.

1,25(OH)2D3 regulates calcium metabolism through its interaction with its major target tissues, the bone and the intestine. Various factors, including serum phosphorus (Pi) and parathyroid hormone (PTH), regulate the renal production of 1,25(OH)2D3.
 

Vitamin D3 at FBL


FBL is a leader in manufacturing Vitamin D3, a business it took over in 2004 from DIL Ltd, the first company to harness technology and manufacture this Vitamin in India. The manufacturing process by DIL was started way back in 1974 under a JV with Philips Duphar. Today, FBL has the distinction of being the only organization in India to manufacture Vitamin D3. The company caters to requirements of all major pharmaceutical, nutraceutical, food and animal feed manufacturers across the globe.

FBL manufactures Vitamin D3 for various requirements like human pharmaceuticals, human food supplements, animal veterinary and animal feed supplements. The company adheres to the best global norms and quality control standards and has been certified by various international bodies for its reliable products and manufacturing facilities.

The manufacturing set up of FBL located at Kullu in Himachal Pradesh and Dahej in Gujarat are modern facilities that cater to worldwide supplies of various grades of Vitamin D3 products and other specialty APIs.
Vitamin D3

 

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Vitamin D3 Formulations - click to open

 

Vitamin D3 Formulations

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