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Vitamin D, in addition to its essential role in maintaining calcium and phosphorus homeostasis and bone health, exhibits notable antiviral and immunomodulatory effects. Vitamin D deficiency impairs immune function and heightens susceptibility to infection, which has been strongly associated with the progression of cervical cancer. Vitamin D is also known to enhance radiation sensitivity by modulating the autophagy process. Fermenta, a leading manufacturer of Vitamin D, presents this D-Essence Newsletter to highlight the latest research on the role of Vitamin D in cervical cancer and its associated factors.
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Vitamin D supplementation might improve radiotherapy response in advanced cervical cancer
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The impact of Vitamin D supplementation on radiotherapy outcomes in advanced cervical cancer patients was evaluated in a randomized controlled trial. Among 123 subjects, 79.7% in the supplementation group had squamous cell carcinoma and the remaining had adenosquamous carcinoma. After 12 weeks, Vitamin D supplementation was significantly associated with a 32.8 ng/ml and 27.5% higher serum Vitamin D levels and complete response rate, respectively, compared to the control group. Additionally, although not significant, tumor size reduction was -9.6 cm³ greater with Vitamin D supplementation Vs. control group.
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| Suardi D et al. Med Sci Monit. 2025 Mar 24;31:e945964 |
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Vitamin D supplementation potentially lowers the persistence of high-risk HPV infection
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The influence of Vitamin D supplementation on HPV infection was analyzed in a retrospective study that enrolled 512 patients. After 6 months of loop electrosurgical excision procedure, Vitamin D supplementation significantly reduced the persistence rate of high-risk HPV by 20.4% compared to placebo and this trend remained consistent through 12 and 18 month follow-ups. Vitamin D supplementation led to greater improvements in metabolic outcomes (insulin, HOMA-IR and triglycerides), as well as inflammation and immune response, and was associated with a lower overall incidence of adverse reactions Vs. placebo.
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| Xu C et al. Afr J Reprod Health. 2024 Oct 31;28(10):88-98 |
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Vitamin D deficiency possibly correlates with cervicovaginal HPV infection
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A systematic review of 7 full-text articles explored the relationship between human papillomavirus (HPV) and serum Vitamin D levels. Almost half of the included studies showed that there was a significant relationship between Vitamin D deficiency and cervicovaginal HPV. Additionally, one study demonstrated that higher cervicovaginal HPV prevalence was associated with less-than-optimal levels of serum Vitamin D (optimal level: ≥30 ng/mL). Another study displayed that deficiency of Vitamin D metabolites can possibly lead to HPV DNA persistence and related cervical intraepithelial neoplasia (P = 0.009). |
| Khalili SM et al. BMC Infect Dis. 2024 Jan 13;24(1):80 |
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Disclaimer: The contents of this issue of ‘D-essence’ have been developed by FourC Healthvistas Pvt. Ltd. for Fermenta Biotech Ltd. (and its group companies) from information published in literature or sources as cited. The information presented in this publication is for general information and educational purpose only, and it shall neither be considered as any claim, nor as a substitute for professional medical advice, nor is intended to diagnose, treat, cure or prevent any disease. Although a great care has been taken in compiling and checking the information, it has not been evaluated by United States Food and Drug Administration or any authority. The authors, FourC Healthvistas Pvt. Ltd., Fermenta Biotech Ltd., and their respective employees, directors, managers, agents & sponsors shall not be responsible and in any way liable for any errors, omissions or inaccuracies in this publication, whether arising out of negligence, mistake or otherwise, and for any consequences arising therefrom.
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All Rights Reserved Fermenta Biotech Ltd.
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