|
|
|
|
Vitamin D deficiency is recognized as a risk factor for numerous health conditions so monitoring its serum level is crucial. Vitamin D is known to regulate immune responses, retain skin barrier function, promote wound healing and prevent skin infections which is essential to maintain skin homeostasis. Fermenta, a leading manufacturer of Vitamin D, presents this D-Essence Newsletter to highlight the latest research on the role of Vitamin D in skin health.
|
|
|
Vitamin D supplementation probably alleviates chronic pruritus
|
|
A meta-analysis of 9 trials evaluated the role of Vitamin D in alleviating chronic pruritus. Among 1,085 individuals, Vitamin D supplementation lowered pruritus (P = 0.03) in patients who experienced itching. While analyzing the duration of intervention, Vitamin D supplementation for < 8 weeks showed greater reduction in pruritus compared to placebo (P = 0.014). The skin lesion area was also reduced significantly with a standard mean difference of -0.82 after Vitamin D administration Vs. placebo. Furthermore, inflammatory cytokines including TNF, IL-6 and hs-CRP levels were lowered with Vitamin D supplementation.
|
| Li CP et al. Int J Mol Sci. 2024 Sep 16;25(18):9983
|
|
|
|  |
|
|
|
Vitamin D supplementation might enhance laser therapy benefits in vitiligo
|
|
|
The efficacy of Vitamin D supplementation with excimer laser (Vs. laser alone - control group) was analyzed in a randomized controlled study which enrolled 26 non-segmental vitiligo patients with low Vitamin D levels (<20 ng/mL). After 6 months, patients with Vitamin D supplementation showed a 52.83% greater improvement in the Vitiligo Area Scoring Index (VASI) score Vs. control group indicating greater reduction in vitiligo depigmentation. Additionally, 75% of the patients experienced >50% improvement in re-pigmentation with Vitamin D. Furthermore, significantly more patients had better overall treatment response (assessed by physician global assessment score) with Vitamin D Vs. control group.
|
| Kim JC et al. J Cosmet Dermatol. 2024 Mar;23(3):839-848 |
|
|
|
|
|
Vitamin D supplementation possibly reduces atopic dermatitis severity
|
|
|
A systematic review and meta-analysis examined the efficacy of Vitamin D supplementation in treating atopic dermatitis (AD) in 686 children and adults. Of 11 included studies, 27% studies showed significant improvement in AD symptoms with Vitamin D supplementation along with substantially greater reduction in AD severity with a standard mean difference of -0.41 compared to the control group. On subgroup analysis, patients with Vitamin D intervention for < 3 months, mild-to-moderate AD severity and Vitamin D dosage of > 1000 IU/day were associated with significant improvement in AD severity Vs. control group.
|
| Nielsen AY et al. Nutrients. 2024 Nov 28;16(23):4128
|
|
|
|
|
|
|
|
Disclaimer: The contents of this issue of ‘D-essence’ have been developed by FourC Healthvistas Pvt. Ltd. for Fermenta Biotech Ltd. (and its group companies) from information published in literature or sources as cited. The information presented in this publication is for general information and educational purpose only, and it shall neither be considered as any claim, nor as a substitute for professional medical advice, nor is intended to diagnose, treat, cure or prevent any disease. Although a great care has been taken in compiling and checking the information, it has not been evaluated by United States Food and Drug Administration or any authority. The authors, FourC Healthvistas Pvt. Ltd., Fermenta Biotech Ltd., and their respective employees, directors, managers, agents & sponsors shall not be responsible and in any way liable for any errors, omissions or inaccuracies in this publication, whether arising out of negligence, mistake or otherwise, and for any consequences arising therefrom.
|
|
|
|
For more information, please visit our public awareness initiative
|
|
|
|
|
|
All Rights Reserved Fermenta Biotech Ltd.
|
|
