Vitamin D deficiency has become a widespread problem resulting in an increased need for its supplementation. Vitamin D deficiency is closely related to various factors associated with chronic illnesses including insulin sensitivity in diabetes, cardiac function as well as chronic kidney disease and thus, its adequacy might help reduce the risk of these chronic diseases. Fermenta, one of the largest manufacturers of Vitamin D, brings to you this Newsletter on the latest research of Vitamin D in Chronic Illness. Vitamin D supplementation might promote healthy outcomes in individuals with hypertension A prospective cohort study evaluated the association between Vitamin D status and mortality in 19,500 hypertensive patients. Vitamin D deficient levels of 25-49.9 nmol/L and <25 nmol/L were associated with a 71% and 97% higher risk of all-cause mortality, respectively Vs. the sufficient group (≥75 nmol/L). Vitamin D supplementation showed a 24% greater risk reduction of all-cause mortality Vs. non-users after multivariable adjustment. This risk reduction was more prominent among those without a history of diabetes and CVD compared to those with a history. High doses of Vitamin D were more strongly associated with low mortality. Ye H et al. Nutr J. 2024 Mar 9;23(1):33 Integration of Vitamin D supplement into conventional medical therapy might be beneficial in T2DM A meta-analysis and systematic review analyzed the impact of Vitamin D supplementation on insulin resistance in diabetes patients. Among 12,306 patients, Vitamin D supplementation showed a greater reduction in serum insulin, glucose and HOMA-IR indicated by standard mean difference of -0.27, -0.17 and -0.44, respectively, thus alleviating insulin resistance as compared to the routine treatment. A significant negative correlation was noted between Vitamin D level and blood glucose and insulin levels. Vitamin D supplementation might be a promising adjuvant to effectively manage T2DM. Lei X et al. Sci Rep. 2023 Jul 31;13(1):12343 Vitamin D level might be a potential biomarker for cardiac function and structure in CKD patients A retrospective cohort study investigated the association of Vitamin D with left ventricular hypertrophy (LVH) and left ventricular diastolic dysfunction (LVDD) in chronic kidney disease patients. Among 513 patients, those with highest level of serum Vitamin D (>21.6 pg/dl) exhibited reduced prevalence of LVH and LVDD Vs. lower level (<11.6 pg/dl and 11.6-21.5 pg/dl). As per multivariable analysis, serum Vitamin D level displayed a sustained independent correlation with LVH and LVDD, associated with 10% and 12% lower odds, respectively. Hyeon J et al. PLoS One. 2024 May 9;19(5):e0302849 Disclaimer: The contents of this scientific issue have been developed by FourC Healthvistas Pvt. Ltd. for Fermenta Biotech Ltd., from reasonable and reliable information published in literature as cited. This is for information purpose only and not a substitute to medical advice. Although great care has been taken in compiling and checking the information, the authors, FourC Healthvistas Pvt. Ltd., Fermenta Biotech Ltd., its employees and/or its agents & sponsors shall not be responsible, or in anyway liable for any errors, omissions or inaccuracies in this publication, whether arising from negligence or otherwise, or for any consequences arising therefrom. For more information, please visit our public awareness initiative All Rights Reserved Fermenta Biotech Ltd.