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Vitamin D plays a crucial role in respiratory health because of its multiple pleiotropic benefits including anti-inflammatory, anti-proliferative and anti-oxidant effects. The ability of Vitamin D to improve innate and adaptive immune response has led to different analysis of its role in therapies for respiratory diseases. Fermenta, one of the largest manufacturers of Vitamin D, brings to you this Newsletter on the latest research of Vitamin D in Respiratory Illness.
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Vitamin D supplementation might reduce asthma severity
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A systematic review analyzed the association between Vitamin D and lung function in children and adults with asthma. Among 1603 patients, there was a positive correlation between Vitamin D levels and lung function parameters (FEV1, FVC, FEV1/FVC). Among patients with severe or uncontrolled asthma, 3 in every 4 had Vitamin D deficiency. Vitamin D deficiency was related to a 5-fold higher risk of severe asthma. In contrast, high Vitamin D level was associated with a 10% lower risk of hospitalization. Additionally, Vitamin D supplementation also showed a 65% lower recurrence rate compared to placebo in children with asthma.
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| Abi-Ayad M et al. Lung India. 2023 Sep-Oct;40(5):449-456 |
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Vitamin D supplementation might reduce rhinosinusitis symptom severity and nasal polyposis recurrence
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A clinical trial analyzed the impact of Vitamin D supplementation on the rhinosinusitis relapse in 60 patients with chronic rhinosinusitis with nasal polyposis (NP) after endoscopic sinus surgery (29 received Vitamin D supplementation and 31 received placebo). As per SNOT-22 questionnaire, Vitamin D significantly reduced the symptom severity by ~7 more points Vs. placebo. After 6 months, NP recurrence was reduced to half with Vitamin D supplementation Vs. placebo. Vitamin D supplementation lowered the chance of NP recurrence by 71% (P=0.032). |
| Ghazavi H et al. Adv Biomed Res. 2023 Feb 25;12:29
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Improved Vitamin D levels might reduce oxidative stress and inflammation in cystic fibrosis
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A cross-sectional study was conducted to evaluate the association between Vitamin D levels, oxidative stress and inflammation markers in 48 patients with cystic fibrosis (CF), including children (5-10 yrs of age), adolescents and adults (20-45 yrs of age). Almost 2 in every 3 patients had Vitamin D deficiency. Vitamin D level was inversely associated with oxidative stress (analysed by an oxidizing marker) only in the presence of inflammatory markers (C-Reactive Protein and Alpha 1-Acid Glycoprotein). This indicated that higher level of Vitamin D reduced the oxidative stress and inflammation that causes lung damage among CF patients.
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| Queiroz DJM et al. Nutr Hosp. 2023 Apr 20;40(2):280-285
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Disclaimer: The contents of this scientific issue have been developed by FourC Healthvistas Pvt. Ltd. for Fermenta Biotech Ltd., from reasonable and reliable information published in literature as cited. This is for information purpose only and not a substitute to medical advice. Although great care has been taken in compiling and checking the information, the authors, FourC Healthvistas Pvt. Ltd., Fermenta Biotech Ltd., its employees and/or its agents & sponsors shall not be responsible, or in anyway liable for any errors, omissions or inaccuracies in this publication, whether arising from negligence or otherwise, or for any consequences arising therefrom.
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