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Vitamin D plays a significant role in maintaining immune homeostasis. As reported in numerous studies, Vitamin D deficiency is associated with abnormal immune responses, chronic inflammation, abnormal glucose metabolism and has the potential to influence cardiovascular health due its biological properties. Fermenta, one of the largest manufacturers of Vitamin D, brings to you this Newsletter on the latest research of Vitamin D in Chronic Diseases.
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Vitamin D supplementation might be associated with lower CV events in older adults
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A randomized, placebo controlled trial conducted among 16,882 participants (60-84 years) analyzed the association between Vitamin D and incidences of cardiovascular (CV) events. At 5 years, Vitamin D supplementation reduced the risk of major CV events by 9% compared to placebo. Vitamin D showed 19% and 11% greater reduction in the risk of myocardial infarction and coronary revascularization, respectively Vs. placebo. Among statin and CV drug users, Vitamin D showed 17% and 16% greater reduction of major CV events compared to non-users. Vitamin D supplementation might have cardioprotective effects in older adults.
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| Thompson B et al. BMJ. 2023 Jun 28;381:e075230 |
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Vitamin D supplementation may improve T2DM biomarkers
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An umbrella review of 37 meta-analysis was carried out to analyze the effect of Vitamin D on T2DM biomarkers. Among 36,197 patients, Vitamin D administration significantly reduced fasting blood sugar, HbA1c, insulin and insulin resistance (calculated by HOMA-IR) levels by 0.26 mg/dl, 0.16%, 0.331 μIU/mL and 0.31. Based on subgroup analysis, Vitamin D significantly improves glycemic status when administered at ≤4000 IU/day dosage for ≤15 weeks as compared to >4000 IU/day. Thus, Vitamin D might be helpful in lowering T2DM biomarkers and managing hyperglycemia. |
| Musazadeh V et al. Diabetol Metab Syndr. 2023 Apr 19;15(1):76
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Vitamin D might improve graft function and exhibit anti-inflammatory effect in kidney transplant recipients
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A prospective cohort study of kidney transplant recipients, treated (n=20) and untreated (n=22) with Vitamin D evaluated the association between Vitamin D, inflammatory cytokines and graft function. In patients treated with Vitamin D, the serum Vitamin D levels peaked at 6-months post-transplant and remained above 30 ng/ml. The eGFR level in Vitamin D group increased gradually and was significantly increased to 71.34 mL/min/1.73 m2 at 12 months post-transplantation compared to 59.47 mL/min/1.73 m2 in untreated group. Vitamin D also decreased the inflammatory cytokines (IL-1β, IFN-γ, IL-2, IL-10, etc.) at 12-months post-transplantation.
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| Bai YJ et al. Front Immunol. 2023 Jul 6;14:1152295
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Disclaimer: The contents of this scientific issue have been developed by FourC Healthvistas Pvt. Ltd. for Fermenta Biotech Ltd., from reasonable and reliable information published in literature as cited. This is for information purpose only and not a substitute to medical advice. Although great care has been taken in compiling and checking the information, the authors, FourC Healthvistas Pvt. Ltd., Fermenta Biotech Ltd., its employees and/or its agents & sponsors shall not be responsible, or in anyway liable for any errors, omissions or inaccuracies in this publication, whether arising from negligence or otherwise, or for any consequences arising therefrom.
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